Ulcerative colitis

What is ulcerative colitis?

Ulcerative colitis is a condition where the large intestine and rectum become inflamed and eventually produce ulcers. It is a type of inflammatory bowel disease, along with Crohn’s disease. Inflammatory bowel disease affects more than 620,000 people in the UK .

Can it be cured?

Ulcerative colitis is a long-term condition, which means it can’t be cured. Instead, treatment focusses on managing the symptoms, and achieving “remission”, where no symptoms occur.

This doesn’t mean that symptoms can’t come back – ulcerative colitis is a fluctuating condition involving “flare-ups” (see below).

Symptoms of ulcerative colitis

The main symptoms of ulcerative colitis include:

  • diarrhoea, often containing blood
  • stomach pain and rectal pain
  • fequently needing to go to the toilet
  • weight loss
  • fatigue

Ulcerative colitis is characterised by “flare-ups”, where symptoms worsen for a period of time, and you can experience symptoms in other parts of the body. These can include:

  • mouth ulcers
  • a high temperature
  • painful and swollen joints
  • irritated eyes

Everyone experiences ulcerative colitis differently. With the right treatment and self-management, some people can experience long periods of “remission” where you only experience mild symptoms, or even none at all.


Diagnosis will usually involve a combination of:

  • taking a stools sample to rule out other conditions such as an infection or colon
  • blood tests to rule out anaemia or inflammation
  • sigmoidoscopy or colonoscopy to see inside your large intestine

Sometimes the doctor might need to do an X-ray to check if there are serious complications, but this is much less common.

What causes ulcerative colitis?

It’s not clear exactly what causes ulcerative colitis. Many health professionals now think that it could be an autoimmune condition, involving the immune system mistakenly attacking healthy cells. This may be triggered by an infection in the large intestine.

However, other factors appear to play a role:

  • you’re more likely to have the condition if a family member has had it
  • having certain genes makes you more likely to have the condition
  • the condition is more common in places with better sanitation

Ulcerative colitis therefore seems to be caused by a combination of genetic and environmental factors.


Treatment for ulcerative colitis includes lifestyle and diet changes, medication, and in very rare cases, surgery.

Lifestyle changes

For some people, making changes to their diet can help control the symptoms and reduce the frequency of “flare-ups”. Some helpful changes can include:

  • Making sure you stay hydrated by drinking plenty of liquids through the day
  • Making sure you have a well-balanced diet with all the vitamins and minerals you need, possibly with the aid of supplements
  • Avoiding foods you have any intolerance to (e.g. avoiding dairy products if you’re lactose intolerant)
  • Eating smaller, more frequent meals, rather than a few large meals


Your doctor may prescribe a combination of drugs to achieve different goals, including:

  • Anti-inflammatory drugs such as aminosalicylates and corticosteroids
  • Immunosuppressants usually used to treat flare-ups, or to treat patients who haven’t responded to anti-inflammatory drugs


Surgery is generally only recommended when a patient hasn’t responded to medication, or are experiencing severe flare-ups that significantly affect their day to day life.

Surgery will involve removing the colon, and replacing its function with an ileostomoy or ileo-anal pouch. This results in a complete cure of the condition.